ADULT HUMAN GLIOBLASTOMAS HARBOR RADIAL GLIA-LIKE CELLS

Adult Human Glioblastomas Harbor Radial Glia-like Cells

Summary: Radial glia (RG) cells are the first neural stem cells to appear during embryonic development.Adult human glioblastomas harbor a subpopulation of RG-like cells with typical RG morphology and markers.The cells exhibit the classic and unique mitotic behavior of normal RG in a cell-autonomous manner.Single-cell Control Box RNA sequencing anal

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Oral hygiene and number of oral mucosal lesion correlate with oral health-related quality of life in elderly communities

Background: Quality of life assessment mostly is based on general health.Deterioration of physiologic condition, polypharmacy and the high occurrence of chronic disease in elderly may manifest in oral cavity that can affect oral function, in turn it will affect quality of life of elderly.Purpose: This study was aimed to determine the correlation of

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PARP inhibitor Olaparib overcomes Sorafenib resistance through reshaping the pluripotent transcriptome in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is one of the most common human malignancies worldwide with very poor prognosis.Resistance to targeted therapeutic drugs such as sorafenib remains one of the major challenges in clinical treatment.In the present study, PARP1 was found to be highly expressed in human embryonic stem cells, but progressively dec

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